Lower-cost compounded GLP-1 programs
Online programs selling compounded semaglutide and tirzepatide, checked against our safety screen. These are not FDA-approved medicines; read the box below before you choose.
Compounded semaglutide and tirzepatide are made by pharmacies, not by Novo Nordisk or Lilly. They are not FDA-approved, they are not generic Wegovy or Zepbound, and the FDA doesn't check their quality before sale. Rules on compounding these drugs are still changing, so a program can change or stop. Brand-name pills now start at $149 a month and Zepbound vials at $299, so compare with the brand-name prices first. Why the rules changed.
| Program | Semaglutide | Tirzepatide | Plan terms | Our checks | Link |
|---|---|---|---|---|---|
| Enhance.MDCompounded semaglutide, tirzepatide, microdose tirzepatide | $212–$249/mo | $280–$329/mo | Month to month, or lower rates on 3-, 6- or 12-month plans | Pharmacy namedLegitScript (claimed)No FDA letter found | Visit site |
| FridaysCompounded semaglutide and tirzepatide; Wegovy also available | $249/mo | $359/mo | Month to month; multi-month plans and first-month promo codes | Pharmacy namedLegitScript not shownNo FDA letter found | Visit site |
| BrightmedsCompounded semaglutide and tirzepatide; brand Zepbound prescriptions | From about $189/mo | From $289 first month | Ongoing price shown after the intake quiz | Pharmacy namedLegitScript not shownNo FDA letter found | Visit site |
| GalaCompounded tirzepatide, microdose tirzepatide | Not offered | $179/mo (microdose $149) | Yearly subscription; no month-to-month price published | Pharmacy not namedLegitScript (claimed)No FDA letter found | Visit site |
| Yucca HealthCompounded semaglutide and tirzepatide | From $146/mo | From $258/mo | Lowest prices on a 6-month plan for new patients | Pharmacy not namedLegitScript (claimed)No FDA letter found | Visit site |
| YourEraCompounded semaglutide and tirzepatide | $149 first month, then $179/mo | $179 first month, then $259/mo | Month to month; lower semaglutide rate with a 6-month commitment | Pharmacy not namedLegitScript (claimed)No FDA letter found | Visit site |
Prices as advertised on each program's site and public price trackers, July–October 2026. Most change often and depend on plan length and promo codes. Confirm the total, renewal price and refund terms before paying.
How we chose these programs
We started from the compounded GLP-1 programs that run affiliate partnerships and removed any we found named in FDA warning letters about compounded GLP-1 marketing in 2025 or 2026. That excluded several well-known programs. Every program listed here also passes at least one of these checks:
- It names the pharmacy that compounds your medicine, so you can look up its state license.
- It shows LegitScript certification, an independent check that online health businesses follow pharmacy and telehealth laws. We list this as "claimed" because certifications can lapse. You can confirm one at legitscript.com.
Programs are ordered by how many checks they pass, then alphabetically. Commissions don't affect the order.
Program by program
What each does well and what to check before signing up.
Enhance.MD
Compounded semaglutide, tirzepatide, microdose tirzepatide
What we like
- Names its partner pharmacies
- Says it holds LegitScript certification
- Full refund of the first payment if a clinician finds you ineligible
Watch out for
- Not available in 10 states
- Shipped medication can't be returned
- Best prices need a 12-month plan
Fridays
Compounded semaglutide and tirzepatide; Wegovy also available
What we like
- Names its partner pharmacies
- Offers brand-name Wegovy too, so you can switch later
- No separate membership on compounded plans
Watch out for
- Highest month-to-month tirzepatide price here
- You can't choose the pharmacy
- Cancel at least 72 hours before billing; most fees non-refundable
Brightmeds
Compounded semaglutide and tirzepatide; brand Zepbound prescriptions
What we like
- Names its partner pharmacies
- Can also prescribe brand Zepbound for a $100 consult fee
- Full refund if you're found ineligible
Watch out for
- Ongoing tirzepatide price isn't published up front
- Charges are non-refundable once medication is ordered
Gala
Compounded tirzepatide, microdose tirzepatide
What we like
- Lowest tirzepatide price in this list
- Says it holds LegitScript certification
- Same price at every dose
Watch out for
- Doesn't publicly name its pharmacy
- Refunds generally not issued after you cancel
- Low price depends on a yearly commitment
Yucca Health
Compounded semaglutide and tirzepatide
What we like
- Low semaglutide starting price
- Displays a LegitScript badge
- Available nationwide
Watch out for
- Doesn't publicly name its pharmacy
- Ongoing dose-based pricing shown only after intake
YourEra
Compounded semaglutide and tirzepatide
What we like
- Same price at every dose
- Says it holds LegitScript certification
Watch out for
- Doesn't publicly name its pharmacy
- No refund once the pharmacy starts processing
- State availability not published
Questions to ask before you pay
- Which pharmacy will make my medicine, and is it licensed in my state?
- Is my dose written in milligrams, and exactly how many units do I draw up?
- Does the price change as my dose goes up?
- What's the renewal price after any first-month promo, and how do I cancel?
- Can I get a refund for medication that hasn't shipped?
- Who do I contact about side effects, and how fast do they reply?
The FDA has received reports of people overdosing on compounded semaglutide, often from confusing units with milligrams. If your syringe markings and your instructions don't clearly match, stop and ask your clinician before injecting.
Prefer brand-name medicine?
Compare online clinics that prescribe Wegovy, Zepbound and the GLP-1 pills.
Sources
- FDA: FDA warns 30 telehealth companies against illegal marketing of compounded GLP-1s
- FDA: Concerns with unapproved GLP-1 drugs used for weight loss
- Telehealth.org: FDA sends new round of warning letters (June 2026)
- Prices, pharmacies and certifications: each program's own website, checked against public price trackers.